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Structural Studies on Three Plant Diterpenoids from Leonotis nepetaefolia
This paper describes the interesting structural studies on three new
diterpenoids (plant products), namely, hydroxy-dialactone nepetaefolinol
(9,13-epoxy-6b-hydroxy-8a-labdane-16,15 :19,20-diolactone), dehydrated
nepetaefolinol (9,13-epoxylabd-5-ene-16,15:19,20-diolactone) and isomeric
Keywords: diterpenoid, leonotis nepetaefolia, hypotensive, antimicrobial, phosphodiesterase inhibitors, pharmacological (Received February 2, 2002; Accepted June 6, 2002)
Recent chemical and biological research has resulted in much evidence
concerning the defensive role of natural products. Natural products, the
structurally diverse compounds act as growth inhibitors, antifeedants,
antimicrobial, deterrents and insecticides. Leonotis nepetaefolia is one of the
41 species of Labiatae spread all over the country. It is used to treat
bronchial asthma, diarrhoea, fever, influenza and malaria, and is also an
Leonotis nepetaefolia is one of the important Ayurvedic herbal drug known as
Grantiparani in Sanskrit. Phytochemical examination of this plant parts yielded
different diterpenoids of labdane type. This plant exhibited various biological
activities viz. antifungal, anti-malarial, anti-cancer, hypotensive and has
attributed to a variety of salutary physiological effects (DAHL and NORMAN,
1970). The essential oil of L.nepetaefolia (Labiate) was tested for its
anti-bacterial activity against both Gram positive and Gram negative bacteria
and was found to be moderately active. The essential oil was also found to be
inhibitory to dermatophytic fungi and suppressive to other aerial fungi. The oil
may be quite useful in skin infections due to dermatophytes even with secondary
bacterial infections (GOPAL, SARATHA VASANTH and VASUDEVAN, 1994). The plant is
reported to be useful in
A decoction of the leaves is used as tonic and to cure burns. The seeds possess feeble anti-malarial acitivity. The seed extract exhibited toxicity against Gram positive and Gram negative bacteria (GOPAL et al., 1995). Ash from the flowers is treated against burns (Wealth of India, 1962). Many species of the wide-spread family Labiatae have been used in primitive medical treatment of cancer. Thus every component of the plant has useful medicinal properties. Fig.1 shows the chemical diagrams of three diterpenoids..
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